Precise.
Personalized.
Proven.
The DecisionDx-Melanoma gene expression profiling (GEP) test empowers you to make more informed decisions and ultimately improve patient care.
The only GEP test associated with improved patient survival1
DecisionDx-Melanoma provides personalized results for patients with stage I-III cutaneous melanoma, guiding risk-aligned management decisions. By combining tumor biology with traditional clinicopathological features, the test offers two critical applications for dermatologists:
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What is the likelihood of sentinel lymph node positivity?
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What is my patient's risk of recurrence or metastasis?
The limitations of staging
While over 90% of melanoma patients are initially diagnosed with stage I or II disease and are frequently assumed to be low risk, this same group accounts for 62% of melanoma-related deaths.*2-6
What does this mean?
- AJCC staging alone is inadequate for predicting clinical outcome
- Many high-risk tumors are being misidentified as low risk at the time of diagnosis
- There is opportunity to increase prognostic accuracy
*excluding stage IV
DecisionDx-Melanoma guides risk-aligned patient management and can improve outcomes
Recent data from an ongoing collaboration with the National Cancer Institute’s (NCI) Surveillance, Epidemiology and End Results (SEER) program registries show that testing with DecisionDx-Melanoma was associated with lower melanoma-specific and overall mortality relative to untested patients. In the study, DecisionDx-Melanoma provided significant and independent risk stratification of patients with cutaneous melanoma, beyond American Joint Committee on Cancer Eighth Edition (AJCC8) stage, which may help inform more personalized patient management decisions.1
Hear from an expert
Shannon Trotter, DO, FAOCD, FAAD, discusses how she uses DecisionDx-Melanoma to personalize care
A real-world case study: How DecisionDx-Melanoma changed management of a stage 1 (T1a) tumor
34-year-old female presented with lesion on the arm
Patient demographics
- 34-year-old, Female
- Invasive malignant melanoma
- 0.6 mm Breslow Depth
- No Ulceration
- No evidence of mitoses
- No TILs present
- No satellitosis
- Clark Level III
Management plan
(Based on AJCC Staging & NCCN Guidelines)
H&P every 6-12 months for five years, then annually.
Rationale for ordering DecisionDx-Melanoma
Because of the patient’s age and Breslow depth being on the thicker end of a thin melanoma, the clinician wanted additional guidance on the management plan for this patient.
Test result & impact to patient care
DecisionDx-Melanoma Result: CLASS 2B Highest Risk
- Referred to medical oncologist for high-intensity surveillance (CT scans every six months).
Outcome
- During the patients 6-month scan, a met to the lung was identified. Biopsy showed it was a proven oligment that was BRAF negative.
- Patient was treated with radiotherapy to the lung and started on combination therapy.
- Patient is doing well with clear scans at more than six years.
Ready to enhance your decision making and improve patient outcomes?
References
- Bailey et al. JCO PO. 2023
- AJCCv8 CA Cancer J Clin. 2017.
- SEER program database (released July 2022)
- Whiteman D et al. J Invest Derm. 2015
- Shaikh W et al. J Natl Cancer Inst. 2016
- Ibrahim et al. Ann Surg Oncol. 2020