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Case Studies
Providing objective data to resolve diagnostic and clinical ambiguity
The following case studies show examples of ambiguous melanocytic lesions and demostrate how gene expression profile testing can provide guidance for difficult-to-diagnose lesions and improve patient management.
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Alexander Witkowski, MD, PhD
Dermatologist
Director, OHSU Skin Cancer Imaging Center
Assistant Professor of Dermatology, School of Medicine
Portland, Oregon
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Babar K. Rao, MD, FAAD
Professor of Dermatology and Pathology
Rutgers Center for Dermatology
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Cary Chisholm, MD
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Clay Cockerell, MD, MBA, JD
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Hadas Skupsky, MD, FAAD
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Etan Marks, DO
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Barry White, MD
Director of Dermatopathology at PathAI Diagnostics
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Drazen Jukic, MD, PhD
Dermatopathologist and Director at Georgia Dermatopathology
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High-risk melanoma diagnosed and risk-stratified with MyPath Melanoma and DecisionDx-Melanoma
A 74-year-old male with a dome-shaped red papule on right central frontal scalp.
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Inconclusive PRAME staining on high-stakes lesion on face
A 34-year-old male with a positive family history of melanoma presents with a lesion on the right lateral malar cheek. It was questionable if the lesion had been previously biopsied.
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Aberrant PRAME expression in acral nevus
A 70-year-old male presented with a atypical melanocytic proliferation on his right instep. He had no personal or family history of melanoma. The clinical diagnosis was acral nevus - rule out atypia.
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Concerning melanocytic lesion in patient with personal history of melanoma
A 49-year-old male was seen by a dermatologist for a concerning nevus on the right superior lateral neck. The patient's age, extensive solar damage, and history of metastatic melanoma was a cause for concern.
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Abnormally pigmented lesion with uncertain malignant potential
A woman in her 30's presents to her dermatologists for evaluation of a isolated lesion with irregular pigmentation on her inner thigh.
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Atypical melanocytic proliferation on sensitive preauricular cheek
A 65-year-old male presented with an atypical melanocytic proliferation near the left ear. Four sites of basal cell carcinoma and seborrheic keratosis were taken at the same visit.
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Multi-colored lesion with uncertain malignant potential
A 80-year-old male presents to a dermatologist with a multi-colored lesion on his back and a previous history of extensive sun damage and non-melanoma skin cancers.
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Irregular papule with atypical histopathological findings and borderline/unknown diagnosis
A 43-year-old female presents to a dermatologist with a suspicious irregular multi-colored papule on the right dorsal foot.
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Asymmetrical pigmented lesion with high clinical suspicion for melanoma
A 27-year-old female was seen by a primary care physician who recommended follow-up with a dermatologist for assessment of a concerning melanocytic lesion.
