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Addition of the 40-gene expression profile (40-GEP) test improves prognostic accuracy and risk stratification for high-risk cutaneous squamous cell carcinoma (HR-cSCC) of the head and neck treated with Mohs micrographic surgery (MMS)
May 2024
Assess the ability of the 40-GEP test to significantly improve metastatic risk prediction of NCCN, AJCC8, and BWH staging systems when included.
DecisionDx-SCC
Cutaneous Squamous Cell Carcinoma
Clinical Utility
Prognostic
Dermatology
Presentation
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A Tissue Systems Pathology Test Outperforms the Standard of Care Variables in Predicting Progression in Patients with Barrett’s Esophagus
August 25, 2023
This study evaluated the predictive performance of a tissue systems pathology test (TissueCypher, TSP-9) versus current clinicopathologic variables in a multi-center cohort of BE patients.
TissueCypher
Barrett's Esophagus
Prognostic
Gastroenterology
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The 31-gene expression profile stratifies recurrence and metastasis risk in patients with cutaneous melanoma
9/30/2021
DecisionDx-Melanoma significantly stratified patient risk for RFS, DMFS, and MSS (p < 0.001) and was a significant, independent predictor of metastatic recurrence (hazard ratio: 5.38; p = 0.014).
DecisionDx-Melanoma
Cutaneous Melanoma
Clinical Utility
Prognostic
Dermatology
Publication
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Imported item 37
9/29/2023
This study evaluates the performance of DecisionDx-Melanoma and the MSKCC nomogram in a head-to-head study in 465 patients withT1 or T2 tumors and known SLN status
DecisionDx-Melanoma
Other
Prognostic
Dermatology
Publication
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A Tissue Systems Pathology Test Enables Risk-Aligned Management of Patients With Non-Dysplastic Barrett’s Esophagus: Case Reports From a Gastrointestinal Surgery Center
9/25/2023
TissueCypher
Barrett's Esophagus
Prognostic
Gastroenterology
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Integrating the melanoma 31-gene expression profile test with clinical and pathologic features can provide personalized precision estimates for sentinel lymph node positivity: an independent performance cohort
9/2024
The i31-GEP identified patients with < 5% risk of SLN positivity who could safely forego SLNB. Combining the 31-GEP with clinicopathologic features for a precise risk estimate can help guide risk-aligned patient care decisions for SLNB to reduce the number of unnecessary SLNBs and increase the SLNB positivity yield if the procedure is performed.
DecisionDx-Melanoma
Cutaneous Melanoma
Validation
Prognostic
Dermatology
Publication
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Integrating 31-Gene Expression Profiling With Clinicopathologic Features to Optimize Cutaneous Melanoma Sentinel Lymph Node Metastasis Prediction
9/13/2021
Validation of integrated 31-GEP (i31-GEP) neural network algorithm incorporating clinicopathologic factors with the continuous 31-GEP score for personalized SLNB positivity risk assessment.
DecisionDx-Melanoma
Cutaneous Melanoma
Validation
Prognostic
Dermatology
Publication
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Appropriate Use Criteria for the Integration of Diagnostic and Prognostic Gene Expression Profile Assays into the Management of Cutaneous Malignant Melanoma: An Expert Panel Consensus-Based Modified Delphi Process Assessment
9/13/2019
Expert panel of 9 dermatologists developed 29 clinical scenarios creating an evidence based framework for AUC recommendations for integration of melanoma GEP tests into clincial practice
DecisionDx-Melanoma
Cutaneous Melanoma
Guidelines
Prognostic
Dermatology
Publication
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Integration of a 31-Gene Expression Profile Into Clinical Decision-Making in the Treatment of Cutaneous Melanoma
8/5/2020
Retrospective review and early experience in utilizing 31-GEP in intermediate melanomas and its effect on clinical management.
DecisionDx-Melanoma
Cutaneous Melanoma
Clinical Utility
Prognostic
Dermatology
Publication
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The Tissue Systems Pathology Test Outperforms Pathology Review in Risk Stratifying Patients With Low-Grade Dysplasia
8/30/2023
This study aimed to compare the risk stratification performance of the TSP-9 test vs benchmarks of generalist and expert pathology.
TissueCypher
Barrett's Esophagus
Prognostic
Gastroenterology
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The tissue systems pathology-9 test provides clinically-impactful risk stratification in patients with Barrett’s esophagus: clinical experience in a multicenter cohort
8/30/2023
This study evaluated the use of the validated, commercially-available tissue systems pathology test (TissueCypher, TSP-9) to risk-stratify BE patients in a large clinical practice cohort.
TissueCypher
Barrett's Esophagus
Prognostic
Gastroenterology
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Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test
8/29/2017
Prospective evaluation of the GEP performance in patients enrolled in two clinical registries for three primary endpoints recurrence-free (RFS), distant metastasis-free (DMFS), and overall survival (OS).
DecisionDx-Melanoma
Cutaneous Melanoma
Clinical Utility
Prognostic
Dermatology
Publication
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