Instrument gauge and type in uveal melanoma fine needle biopsy: implications for diagnostic yield and molecular prognostication
Gene expression profiling in uveal melanoma: five-year prospective outcomes and meta-analysis
The prognostic 15-gene expression profile (15-GEP) test for uveal melanoma (UM) predicts metastatic risk based on primary tumor biology. Here we report outcomes from a prospective registry of 15-GEP-tested patients, and a meta-analysis with published cohorts.
Publication: Ocul Oncol Pathol
Gene expression profiling prognostication of posterior uveal melanoma
Investigate the influence of tumor size by American Joint Committee on Cancer (AJCC) stage, Collaborative Ocular Melanoma Study (COMS) size, tumor largest basal diameter (LBD), and tumor thickness on prognostication by gene expression profiling (GEP) class.
Publication: Ophthalmology Retina
Prospective evaluation of risk-appropriate management of uveal melanoma patients informed by gene expression profiling
The multicenter Clinical Application of DecisionDx-UM Gene Expression Assay Results study provides prospective validation of the clinical utility of the 15-gene expression profile test in directing metastatic surveillance imaging, follow-up and referral patterns.
Publication: Melanoma Management
Next-generation sequencing of uveal melanoma for detection of genetic alterations predicting metastasis
Gene expression profiling and PRAME status versus tumor-node-metastasis staging for prognostication in uveal melanoma
Do largest basal tumor diameter and the American Joint Committee on Cancer's cancer staging influence prognostication by gene expression profiling in choroidal melanoma
Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics
A 15-gene expression profile test has been clinically validated and is widely utilized in newly diagnosed uveal melanoma (UM) patients to assess metastatic potentila of the tumor. As most patients are treated with eye-sparing rediotherapy, there is limited tumor tissue available for testing, and technical reliability and success of prognostic testing are critical. This study assessed the analytical performance of the 15-gene expression test for UM and the correlation of molecular class with pathologic characteristics.
Publication: Diagnostic Pathology
Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in class 1 and class 2 uveal melanomas
We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive PRAME expression (PRAME+) in a large dataset, identify factors associated with PRAME expression, evaluate the prognostic value of PRAME in Class 2 uveal melanomas, and determine whether PRAME expression is associated with aberrant hypomethylation of the PRAME promoter.
Driver mutations in uveal melanoma: associations with gene expression profile and patient outcomes
Prognostic implications of tumor diameter in association with gene expression profile for uveal melanoma
Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis.
Publication: JAMA Ophthalmol.