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A Tissue Systems Pathology Test Enables Risk-Aligned Management of Patients With Non-Dysplastic Barrett’s Esophagus: Case Reports From a Gastrointestinal Surgery Center

September 25, 2023
TissueCypher
Barrett's Esophagus
Author: Tseng D,(et al)
Publication: Foregut: The Journal of the American Foregut Society
Prognostic
Gastroenterology
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The Tissue Systems Pathology Test Outperforms Pathology Review in Risk Stratifying Patients With Low-Grade Dysplasia

August 30, 2023
This study aimed to compare the risk stratification performance of the TSP-9 test vs benchmarks of generalist and expert pathology.
TissueCypher
Barrett's Esophagus
Author: Khoshiwal AM, Frei NF (et al)
Publication: Gastroenterology
Prognostic
Gastroenterology
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The tissue systems pathology-9 test provides clinically-impactful risk stratification in patients with Barrett’s esophagus: clinical experience in a multicenter cohort

August 30, 2023
This study evaluated the use of the validated, commercially-available tissue systems pathology test (TissueCypher, TSP-9) to risk-stratify BE patients in a large clinical practice cohort.
TissueCypher
Barrett's Esophagus
Author: Villa NA (et al)
Publication: Diseases of the Esophagus
Prognostic
Gastroenterology
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A Tissue Systems Pathology Test Outperforms the Standard of Care Variables in Predicting Progression in Patients with Barrett’s Esophagus

August 25, 2023
This study evaluated the predictive performance of a tissue systems pathology test (TissueCypher, TSP-9) versus current clinicopathologic variables in a multi-center cohort of BE patients.
TissueCypher
Barrett's Esophagus
Author: Davison JM (et al)
Publication: Clinical and Translational Gastroenterology
Prognostic
Gastroenterology
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31-Gene Expression Profile Testing in Cutaneous Melanoma and Survival Outcomes in a Population-Based Analysis: A SEER Collaboration

June 29, 2023
Study data from Castle Biosciences' collaberation with the National Cancer Institutes SEER program registries.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Bailey, CN (et al)
Publication: JCO-PO
Prognostic
Dermatology
Publication
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Independent Blinded Validation of a Tissue Systems Pathology Test to Predict Progression in Patients with Barrett’s Esophagus

June 20, 2023
A risk prediction test identifies patients with non-dysplastic Barrett's esophagus who are at high risk for progression to high-grade dysplasia or cancer.
TissueCypher
Barrett's Esophagus
Author: Jon M Davison (et al.)
Publication: American Journal of Gastroenterology
Validation
Prognostic
Gastroenterology
Publication
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Incorporation of the 40-Gene Expression Profile (40-GEP) Test to Improve Treatment Decisions in High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) Patients: Case Series and Algorithm

May 5, 2023
Cutaneous squamous cell carcinoma (cSCC) has become a significant public health issue due to its rapidly rising incidence and an estimated 1.8 million newly diagnosed cases annually. As with other cancers, treatment decisions for patients with cSCC are based primarily on a patient’s risk for poor outcomes.
DecisionDx-SCC
Cutaneous Squamous Cell Carcinoma
Author: Gaurav Singh
Publication: Clinical, Cosmetic and Investigational Dermatology
Clinical Utility
Prognostic
Dermatology
Publication
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A Tissue Systems Pathology Test Objectively Risk Stratifies Barrett’s Esophagus Patients with Low Grade Dysplasia

April 21, 2023
The risk prediction assay provided significant risk stratification in BE patients with LGD and identified progressors that the experts downstaged to NDBE.
TissueCypher
Barrett's Esophagus
Author: Nicola F Frei (et al.)
Publication: American Journal of Gastroenterology
Validation
Prognostic
Gastroenterology
Publication
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Routine imaging guided by a 31-gene expression profile assay results in earlier detection of melanoma with decreased metastatic tumor burden compared to patients without surveillance imaging studies

March 28, 2023
Independent mulit-center study demonstrates risk-aligned treatment plans guided by DecisionDx-Melanoma lead to better patient outcomes.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Dhillon, S (et al)
Publication: Archives of Derm Research
Clinical Utility
Prognostic
Dermatology
Publication
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The 31-gene expression profile test informs sentinel lymph node biopsy decisions in patients with cutaneous melanoma: results of a prospective, multicenter study

January 16, 2023
DecisionDx-Melanoma test results influenced 85% of clinicians’ decisions regarding the SLNB surgical procedure. Use of the test results could help avoid unnecessary procedures in low-risk patients whose tumor biology indicates they could safely forgo the procedure.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Maki Yamamoto
Publication: Current Medical Research and Opinion
Clinical Utility
Prognostic
Dermatology
Publication
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TissueCypher: A Systems Biology Approach to Anatomic Pathology

January 15, 2023
A quantitative, multiplexed biomarker imaging approach termed TissueCypher™ that applies systems biology to anatomic pathology.
TissueCypher
Barrett's Esophagus
Author: Jeffrey W. Prichard (et al.)
Publication: Journal of Pathology Informatics
Review Article
Prognostic
Gastroenterology
Publication
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Improved prognostic guidance by the 31-gene expression profile test for clinical decisions after a negative lymph node for patients with cutaneous melanoma

January 13, 2023
Using 31-GEP results to guide clinical management and surveillance based on personalized risk of MSS can direct care, improving patient outcomes.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Brian Martin
Publication: Poster, presented at Winter Clinical Dermatolog conference- Hawaii Jan 13-18 2023
Clinical Utility
Prognostic
Dermatology
Poster
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