Case Study

This is the case of a 60-year-old female patient with long-segment non-dysplastic Barrett’s esophagus and a complicated medical history including a tumor of the rectum. Dr. Loewe utilized a low-risk TissueCypher score to downstaging care.

“Now we have the ability with TissueCypher to allay the patient’s anxiety and reassure the physician that he is doing the right thing for the right patient.”

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Case details

RELEVANT MEDICAL HISTORY
ADDITIONAL CONSIDERATIONS
  • No family history of EAC
  • BMI 26
  • 5-year history of long segment NDBE
  • Chronic GERD
  • Daily PPI use: Omeprazole with sodium bicarbonate
  • History of lateral spreading granular tumor of rectum in 2014
  • History of breast cancer and mastectomy
  • Family history of lung cancer and colon cancer
  • Hashimoto's disease

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DecisionDx-SCC Case Studies
Case Study

This is the case of a 60-year-old female patient with long-segment non-dysplastic Barrett’s esophagus and a complicated medical history including a tumor of the rectum. Dr. Loewe utilized a low-risk TissueCypher score to downstaging care.

“Now we have the ability with TissueCypher to allay the patient’s anxiety and reassure the physician that he is doing the right thing for the right patient.”

‍

Case details

RELEVANT MEDICAL HISTORY
ADDITIONAL CONSIDERATIONS
  • No family history of EAC
  • BMI 26
  • 5-year history of long segment NDBE
  • Chronic GERD
  • Daily PPI use: Omeprazole with sodium bicarbonate
  • History of lateral spreading granular tumor of rectum in 2014
  • History of breast cancer and mastectomy
  • Family history of lung cancer and colon cancer
  • Hashimoto's disease

See other cases with Dr. Loewe

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DecisionDx-Melanoma Case Studies
Case Study

This is the case of a 60-year-old female patient with long-segment non-dysplastic Barrett’s esophagus and a complicated medical history including a tumor of the rectum. Dr. Loewe utilized a low-risk TissueCypher score to downstaging care.

“Now we have the ability with TissueCypher to allay the patient’s anxiety and reassure the physician that he is doing the right thing for the right patient.”

‍

Case details

RELEVANT MEDICAL HISTORY
ADDITIONAL CONSIDERATIONS
  • No family history of EAC
  • BMI 26
  • 5-year history of long segment NDBE
  • Chronic GERD
  • Daily PPI use: Omeprazole with sodium bicarbonate
  • History of lateral spreading granular tumor of rectum in 2014
  • History of breast cancer and mastectomy
  • Family history of lung cancer and colon cancer
  • Hashimoto's disease

See other cases with Dr. Loewe

View all cases

MyPath Melanoma Case Studies
Dr. Charles Loewe: Case 3

Downstaging a female patient with elevated clinical risk

This is the case of a 60-year-old female patient with long-segment non-dysplastic Barrett’s esophagus and a complicated medical history including a tumor of the rectum. Dr. Loewe utilized a low-risk TissueCypher score to downstaging care.

“Now we have the ability with TissueCypher to allay the patient’s anxiety and reassure the physician that he is doing the right thing for the right patient.”

‍

Clinical risk factors

A 60-year-old female patient with a complicated clinical history including Hashimoto’s disease, a tumor of the rectum, breast cancer, and a family history of lung and colon cancer.  

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RELEVANT MEDICAL HISTORY
  • No family history of EAC
  • BMI 26
  • 5-year history of long segment NDBE
  • Chronic GERD
  • Daily PPI use: Omeprazole with sodium bicarbonate
ADDITIONAL CONSIDERATIONS
  • History of lateral spreading granular tumor of rectum in 2014
  • History of breast cancer and mastectomy
  • Family history of lung cancer and colon cancer
  • Hashimoto's disease

Endoscopic findings

The endoscopy confirmed the persistence of long-segment non-dysplastic Barrett’s esophagus.

Lower esophagus:
  • BE segment: C7M9
  • 1.5 cm hiatal hernia​
  • Non-dysplastic pathology
  • Concurrent acute  and chronic reflux esophagitis with  reactive epithelial atypia
Traditional Management:
  • Clinical profile: High risk
  • Treatment recommendation: 3-year surveillance

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TissueCypher results

Dr. Loewe leveraged a low-risk TissueCypher score and share decision making to extend the surveillance interval from 3 to 5 years for this patient.  

  • Risk class: Low
  • Risk score: 3.4
  • 5-year risk of progression: 2%

TissueCypher-guided management

  • Change in management: Downstaged

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“Now we have the ability with TissueCypher to allay the patient's anxiety and reassure the physician that he is doing the right thing for the right patient.”

Charles Loewe, MD

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See other cases with Dr. Loewe