Cases with Jay Yepuri, MD, FACG

Aligning patient care with personal risk

Jay Yepuri, MD, FACG has a great view of the gastroenterology landscape. He is a practicing gastroenterologist in the Dallas/Fort Worth area as well as the current ACG Governor for Texas, Vice Chairman of the Clinical Governance Board for GI Alliance, and a member of the Physician Executive Board for GI Alliance.

For patients with Barrett’s esophagus (BE), Dr. Yepuri is a proponent of using endoscopic eradication therapies (EET) for those with a high risk of progression to esophageal cancer. However, those therapies have a small risk of adverse events, so it is important to determine which patients can benefit most from EET to prevent esophageal cancer.

“The strength TissueCypher offers is the ability to determine, ‘Is it worth putting this patient through the risk of EET, or are we able to do the right thing for the patient by de-escalating from EET to standard surveillance based on guidelines?’”

Dr. Yepuri shared a few cases with us to show how he is leveraging the objective data provided by TissueCypher to make risk-aligned management decisions for patients with Barrett's esophagus.

See Dr. Yepuri's TissueCypher case studies

Confirming low risk of progression in a young female patient

Listen to how Dr. Yepuri handled the case of a young female patient who received an unexpected diagnosis of Barrett's esophagus.

"We're going to be seeing more of these patients that don't quite fit that demographic profile of your typical patient with Barrett's — expect to see more people like this."

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A patient with multiple EGDs and conflicting endoscopic findings

This case of a 75-year-old female required Dr. Yepuri to weigh multiple conflicting data points to recommend the best care for an anxious patient.

"TissueCypher allows us to hone in on what the most relevant factors for consideration of eradication therapy for this patient were... and allow us to take that to a patient who had a lot of anxiety around undergoing multiple invasive procedures."

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Downstaging a female patient with elevated clinical risk

This is the case of a 60-year-old female patient with long-segment non-dysplastic Barrett’s esophagus and a complicated medical history including a tumor of the rectum. Dr. Loewe utilized a low-risk TissueCypher score to downstaging care.

“Now we have the ability with TissueCypher to allay the patient’s anxiety and reassure the physician that he is doing the right thing for the right patient.”

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The strength TissueCypher offers is the ability to determine, ‘Is it worth putting this patient through the risk of EET, or are we able to do the right thing for the patient by de-escalating from EET to standard surveillance based on guidelines?'"

Jay Yepuri, MD, FACG