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Empowering people, informing care decisions.
At Castle, it all comes down to people. After all, disease doesn’t just happen — it happens to people. We believe that disease management and treatment decisions can be better informed through a person’s unique biology, which is revealed through the scientific rigor of our innovative tests. We are committed to empowering healthcare providers and patients with the goal of improved outcomes.
About UsClinical focus areas
Our broad portfolio of innovative tests focuses on answering critical clinical questions. From individualized risk of melanoma metastasis to customized medication profiles for mental health conditions, our tests are designed to deliver personalized information that better informs care decisions.
Dermatology
Gastroenterology
Mental Health
Ophthalmology
Our tests
Cutaneous Melanoma
Make more confident, more accurate treatment plan decisions for sentinel lymph node biopsy guidance as well as surveillance and therapeutic interventions.
Make more confident, more accurate diagnostic decisions with genomic insight for melanocytic lesions.
Cutaneous Squamous Cell Carcinoma (SCC)
Make more confident, more accurate treatment plan decisions for surveillance and therapeutic interventions.
Barrett’s Esophagus
Go beyond tissue morphology to predict a patient’s individualized risk of progression to esophageal cancer in Barrett’s esophagus.
Mental Health
Comprehensive pharmacogenomic (PGx) testing that guides personalized mental health medication selection, tailored to each patient's unique profile.
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Uveal Melanoma
Make more informed, risk-aligned treatment plan decisions based on comprehensive molecular profiling.
Featured spotlights
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Second independent study confirms the ability of DecisionDx-SCC to predict likelihood of benefit from adjuvant radiation therapy in patients with high-risk cutaneous squamous cell carcinoma
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Castle Biosciences and skin cancer survivor Teddi Mellencamp Arroyave launch campaign to increase awareness of melanoma
Castle Biosciences has joined forces with television personality, wellness coach and founder of ALL IN by Teddi, host of the Two T’s in a Pod podcast and stage II melanoma survivor Teddi Mellencamp Arroyave to raise awareness around the prevention, detection and management of melanoma, the deadliest form of skin cancer. The campaign will focus on empowering patients impacted by the disease.
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Explore on-demand MyPath Melanoma case study webinars
Listen to multiple clinicians discuss how gene expression profile testing can provide guidance for difficult-to-diagnose lesions and improve patient management.
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Largest prospective study to date of patients with uveal melanoma further supports performance of DecisionDx-UM for metastatic risk stratification and highlights PRAME as a valuable adjunct biomarker for further risk refinement when considered in conjunction with a DecisionDx-UM result
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TissueCypher Barrett’s esophagus assay impacts clinical decisions in the management of patients with Barrett’s esophagus
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Pharmacogenomic characteristics and IDgenetix-guided medication management for older adults with depression and anxiety
Poster presented at the annual American Association for Geriatric Psychiatry conference in Atlanta, GA on March 15, 2024.
Relentless pursuit of the best outcomes
At Castle, we combine innovation, advanced technologies and relevant real-world evidence to address critical unmet clinical needs and improve health outcomes.
The validity and utility of Castle’s innovative tests has been demonstrated in more than 140 peer-reviewed publications, and more than 200,000 test reports have been delivered to clinicians since 2008 to guide improved disease management decisions for patients.
The latest
News
Press Release
Castle Biosciences to Present at the Piper Sandler 36th Annual Healthcare Conference
Press Release
Castle Biosciences Earns a Houston Chronicle Top Workplaces Award for the Fourth Consecutive Year
Press Release
Castle Biosciences to Present New Data Highlighting the Clinical Performance of DecisionDx®-Melanoma and My...
We are transforming disease management. Join in the transformation.
Every employee at Castle has an impact on patient care. If you are interested in making a difference in the lives of patients while doing something that inspires you, find out what exciting opportunities are available within our team.
