Empowering people, informing care decisions.

At Castle, it all comes down to people. After all, disease doesn’t just happen — it happens to people. We believe that disease management and treatment decisions can be better informed through a person’s unique biology, which is revealed through the scientific rigor of our innovative tests. We are committed to empowering healthcare providers and patients with the goal of improved outcomes.

About Us

Clinical focus areas

Our broad portfolio of innovative tests focuses on answering critical clinical questions. From individualized risk of melanoma metastasis to customized medication profiles for mental health conditions, our tests are designed to deliver personalized information that better informs care decisions.

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Mental Health

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Our tests

Cutaneous Melanoma

Make more confident, more accurate treatment plan decisions for sentinel lymph node biopsy guidance as well as surveillance and therapeutic interventions.

Make more confident, more accurate diagnostic decisions with genomic insight for melanocytic lesions.

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Cutaneous Squamous Cell Carcinoma (SCC)

Make more confident, more accurate treatment plan decisions for surveillance and therapeutic interventions.

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Barrett’s Esophagus

Go beyond tissue morphology to predict a patient’s individualized risk of progression to esophageal cancer in Barrett’s esophagus.

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Mental Health

Comprehensive pharmacogenomic (PGx) testing that guides personalized mental health medication selection, tailored to each patient's unique profile.

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Uveal Melanoma

Make more informed, risk-aligned treatment plan decisions based on comprehensive molecular profiling.

Relentless pursuit of the best outcomes

At Castle, we combine innovation, advanced technologies and relevant real-world evidence to address critical unmet clinical needs and improve health outcomes.

The validity and utility of Castle’s innovative tests has been demonstrated in more than 140 peer-reviewed publications, and more than 200,000 test reports have been delivered to clinicians since 2008 to guide improved disease management decisions for patients. 

The latest


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Castle Biosciences to Release Second Quarter 2024 Financial Results and Host Conference Call on Monday, Aug...

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Castle Biosciences Honored with Top Workplaces Awards

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Recent AGA Clinical Practice Guideline Acknowledges That Individuals Who May Be at Increased Risk of Progre...

We are transforming disease management. Join in the transformation.

Every employee at Castle has an impact on patient care. If you are interested in making a difference in the lives of patients while doing something that inspires you, find out what exciting opportunities are available within our team.

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