DecisionDx-Melanoma: A gene expression profile test for melanoma
Prognostic testing that provides comprehensive, personalized, information to guide management for patients with cutaneous melanoma
How DecisionDx-Melanoma helps personalize your care
DecisionDx®-Melanoma is a genomic test that looks at your own tumor’s biology (usually from your original biopsy) to better understand your personal risk of your tumor spreading (metastasis), coming back (recurring or returning) within the next 5 years, and the chance of sentinel lymph node positivity (where melanoma often first spreads). DecisionDx-Melanoma has been validated in those with stage I-III melanoma.2
DecisionDx-Melanoma uses a small sample of your tumor (melanoma tissue) to measure the activity of 31 specific genes found to be associated with melanoma progression, specifically recurrence (cancer comes back) and metastasis (spreading). Based on your tumor’s activity levels, DecisionDx-Melanoma classifies your personal tumor as lowest risk (Class 1A), increased risk (Class 1B/2A), or highest risk (Class 2B).i
Generally, doctors give risk assessments based on cancer statistics from studies of people in similar situations (population statistics, or risk). These statistics describe what happens in groups of people defined by certain characteristics, such as age, biological sex, size of tumor. For melanoma, this includes measurements such as Breslow thickness, ulceration, and more.ii Because every patient's tumor is unique, with DecisionDx-Melanoma you get a personal risk assessment specific only to you.
Only 20% of people with malignant melanoma have melanoma in their sentinel node,iii sentinel lymph node biopsy (SLNB, the surgery to remove the node(s)) does not impact overall survival, and SNLB comes with certain risksiv that should be discussed with your doctor.
DecisionDx-Melanoma can help doctors determine you likelihood of needing a SLNB, or not, when added to clinicopathological features information (signs and symptoms you experience plus results of other laboratory studies and the review of melanoma tissue from your biopsy).1,3,v
For those with SLN-negative disease, results show if you are at high risk for recurrence or death from melanoma even though you are considered to be low risk by the traditional American Joint Committee on Cancer (AJCC) staging standards.1
DecisionDx-Melanoma results help you and your cancer care team make decisions about your treatment, follow-up appointments, referrals, and the sentinel lymph node biopsy (SLNB) surgical procedure. In fact, 1 out of every 2 people who get a DecisionDx-Melanoma test have a change made to their melanoma treatment plan for at least one of the following: frequency of doctor visits, lab work, or surveillance (monitoring) imaging.6
Our test informs two important decisions
What's the right monitoring plan for my melanoma?
For follow-up management plan decisions, knowing the risk of your cancer recurring is a critical part of developing an effective monitoring plan. Having additional personalized information from DecisionDx-Melanoma can help you and your healthcare professional make better decisions about treating and managing your melanoma.
Is sentinel lymph node biopsy right for me?
For many patients eligible for the sentinel lymph node biopsy (SLNB) surgical procedure, the DecisionDx-Melanoma test can provide important information to consider before deciding to have this procedure.
Backed by data and validated in real world practice
technical success rate in 53,000+ clinical samples
patients tested since 2015
healthcare professionals have ordered the test
of clinical management plans change based on DecisionDx-Melanoma test results
DecisionDx-Melanoma – helping physicians and patients
How personalized medicine is showing that traditional views on staging may need to change and how DecisionDx-Melanoma is helping physicians better personalize care.
Morgan’s Stage 2 melanoma diagnosis journey and how her DecisionDx-Melanoma test helps her manage her anxiety about her melanoma.
How doctors are using DecisionDx-Melanoma and how it helps them make decisions for those in their care who are living with melanoma.
Ask your doctor for DecisionDx-Melanoma — the GEP test that personalizes your risk assessment.
Coverage for DecisionDx-Melanoma
Castle Biosciences is committed to providing high-quality molecular testing to all patients. We do not want financial concerns to be a barrier to you accessing critical healthcare information.
We intend to work with all insurance providers, including Medicare, Medicaid, commercial insurers, and Veterans Affairs (VA), to secure payment coverage for our testing.
For those who may need additional assistance with with their Castle test, we offer a comprehensive patient assistance program.