Scientific Evidence

An objective fully-automated Barrett's risk prediction assay outperforms most pathologists in risk stratifying Barrett's esophagus with low-grade dysplasia

Apr 2022

Histological review of community-based LGD showed a high inter-observer variability with a signification number of cases classified as non-informative.

Author: Khoshiwal AM, et al.

Publication: Podium presentation (OP079) at ESGE 2022, Prague

An objective fully-automated Barrett's risk prediction assay outperforms most pathologists in risk stratifying Barrett's esophagus with low-grade dysplasia

Apr 2022

Histological review of community-based LGD showed a high inter-observer variability with a signification number of cases classified as non-informative.

Author: Khoshiwal AM, et al.

Publication: Podium presentation (OP079) at ESGE 2022, Prague

Tissue systems pathology test objectively risk stratifies Barrett’s esophagus patients with low-grade dysplasia

Apr 2021

The risk prediction assay provided significant risk stratification in BE patients with LGD and identified progressors that the experts downstaged to NDBE.

Author: Frei NF, et al.

Publication: American Journal of Gastroenterology

The TissueCypher® Barrett’s esophagus assay impacts clinical decisions in the management of patients with Barrett’s esophagus

Mar 2021

The TissueCypher test may enable physicians to target EET for high-risk BE patients, while reducing unnecessary procedures in low-risk patients.

Author: Diehl DL, et al.

Publication: Endoscopy International Open

The TissueCypher® Barrett’s esophagus assay impacts clinical decisions in the management of patients with Barrett’s esophagus

Mar 2021

The TissueCypher test may enable physicians to target EET for high-risk BE patients, while reducing unnecessary procedures in low-risk patients.

Author: Diehl DL, et al.

Publication: Endoscopy International Open

Independent validation of a tissue systems pathology assay to predict future progression in non-dysplastic Barrett’s esophagus: a spatial-temporal analysis

Oct 2020

Assessing additional spatial and temporal biopsies increased the predictive accuracy, allowing for identification of most future progressors.

Author: Frei NF, et al.

Publication: Clinical and Translational Gastroenterology

Independent blinded validation of a tissue systems pathology test to predict progression in patients with Barrett’s esophagus

Jun 2020

A risk prediction test identifies patients with non-dysplastic Barrett's esophagus who are at high risk for progression to high-grade dysplasia or cancer.

Author: Davison JM, et al.

Publication: American Journal of Gastroenterology

Independent blinded validation of a tissue systems pathology test to predict progression in patients with Barrett’s esophagus

Jun 2020

A risk prediction test identifies patients with non-dysplastic Barrett's esophagus who are at high risk for progression to high-grade dysplasia or cancer.

Author: Davison JM, et al.

Publication: American Journal of Gastroenterology

Independent validation of TissueCypher to predict future progression in non- dysplastic Barrett’s esophagus: a spatial-temporal analysis

May 2020

An independent validation study showed TissueCypher identified a significant subset of NDBE patients who progress at a rate comparable to expert-confirmed LGD.

Author: Frei NF, et al.

Publication: Poster presentation (Sa1189) at DDW 2020, Virtual

Prediction of neoplastic progression in Barrett’s esophagus by pathologic assessment of degree of crypt atypia and by TissueCypher

May 2020

TissueCypher provided superior risk stratification that outperformed crypt atypia scores.

Author: Odze R, et al.

Publication: Poster presentation (Sa1203) at DDW 2020, Virtual

Independent validation of TissueCypher to predict progression in community- based Barrett's esophagus with low-grade dysplasia: analysis in a completed prospective study

May 2020

TissueCypher may be a practical and effective solution to the lack of standardization of expert pathology review if LGD as advocated by all guidelines.

Author: Frei NF, et al.

Publication: Podium presentation (1085) at DDW 2020, virtual

Independent validation of TissueCypher to predict progression in community- based Barrett's esophagus with low grade dysplasia: analysis in a completed prospective study

May 2020

 

TissueCypher stratified BE patients with a community-based diagnosis of LGD with diagnostic accuracy comparable to three renowned expert pathologists.

 

Author: Frei NF, et al.

Publication: Podium presentation (1085) at DDW 2020, Virtual