Tseng Case Study 1 | TissueCypher

TissueCypher reveals a missing critical detail

A 69-year old male Barrett’s esophagus (BE) patient arrived at Dr. Tseng’s practice after moving to Oregon from another state. The patient was anxious about his BE, but that concern is common for many BE patients who know that they have a precancerous condition and feel uncertain about their risk of developing cancer.

Read the case details below.

Clinical risk factors

69-year-old, male, white

The 69-year-old male BE patient presented to Dr. Tseng with mixed clinical risk factors. He had no relevant family history, but was obese with chronic GERD and a history of smoking. He was aware he had BE.

RELEVANT MEDICAL HISTORY
- No relevant family history
- Obese
- Chronic GERD
- Currently using PPIs
- History of smoking
ADDITIONAL CONSIDERATIONS
- High anxiety
- In surveillance for NDBE

Endoscopic findings

Dr. Tseng performed an upper endoscopy and collected biopsies, revealing a Prague classification of C3M4, no hiatal hernia, and a diagnosis of non-dysplastic Barrett’s esophagus. Traditional – yet subjective – management based on these findings would be surveillance at a one-year interval.

Lower esophagus:

BE segment length: Prague C3M4
No hiatal hernia
Pathology returned non-dysplastic (NDBE)

Traditional Management:

Low risk clinical profile due to NDBE
Treatment recommendation: 1 yr. surveillance due to anxiety and long segment

Endoscopy image from lower third of the esophagus showing salmon-colored mucosa and no visible lesions

TissueCypher results

When the TissueCypher results arrived, Dr. Tseng was concerned by the high-risk score and 14% probability of progression over 5 years. That prompted Dr. Tseng to have a discussion with the patient during which the prior diagnosis of EAC was revealed, and the patient agreed to move forward with radio-frequency ablation to remove his BE.

Risk class: High
Risk score: 6.7
5-year risk of progression: 14%

TissueCypher-guided management